In this article, we have examined the possible influence of hemispheric solar activity features on the interplanetary plasma parameters. For this purpose, the daily data of sunspot areas (SSAs) and sunspot numbers (SSNs) as well as the interplanetary plasma parameters (interplanetary magnetic field (IMF) magnitude B, plasma density n, plasma velocity V, plasma temperature T, and plasma dynamic pressure P) during the period 1967 ̶ 2017 have been used. The daily data of each interplanetary plasma parameter has been classified into two groups, northern (N) and southern (S) sorted groups based on the dominance of hemispheric SSAs or SSNs. The yearly averages of the sorted N and S groups have been calculated for each plasma parameter. The asymmetry index (N-S) for each parameter between the northern and the southern sorted group has been calculated. The asymmetry of B over the solar activity cycles is not detectable, indicating that the solar cycles are magnetically symmetric, in agreement with the findings of (El-Borie et al., 2018a). During the solar cycles 20, 21, and 24, the solar plasma for the southern sorted group was faster (hotter) by 20.3 km/s (15.7×103 oK), 13 km/s (8×103 oK), and 29 km/s (14.5×103 oK) than that for the northern sorted group, respectively. In contrast, during the solar cycle 23, the solar plasma for the southern sorted group was slower (colder) by 7.4 km/s (7.2×103 oK) than that for the northern sorted one.