The revaluation of information technologies nowadays encourages the reliance on Digital Leadership within the business environment using innovative solutions and digital technologies. National Regulators for safety, security and safeguard face huge challenges to meet this specific mandated and establish an optimized regulatory practice for nuclear and radiation facilities and activities. Digital leadership plays a big role to highlight the area of the interface, identify opportunities, enhance organization culture, and encourage risk-informed decisions. This work introduces the Integrated Tool for Leadership and Knowledge Management for Safety and Security (ITLKMSS). It is tailed with specific requirements to create an automated infrastructure with five modules; Knowledge Management portal, Human Resource Development, and Training Centre, Sarcoma-Plus, Staff Information Database, and e-Learning Portal. The tool is developed and tested In-house for a planned scenario to measure its effectiveness. Results support the national efforts for digitalization and help to grantee sustainability of the regulatory framework with effective performance in a challenging context.