Nuclear Knowledge Management (NKM) is an important pillar for the capacity building program of the regulatory body. It is handled as a long term investment that yields to excellence, effectiveness, and risk management of critical knowledge. Recently, the requirements for optimization and sustainability have led to increased interest in business intelligence and knowledge management domains. In general, the nuclear industry is knowledge-based, as it relies on skilled workers and their know-how. Newcomer countries face common challenges related to brain drain, data overloads, and aging of the qualified workforce that could lead to loss of nuclear knowledge. As a result the need to develop the regulatory practices to ensure that interested parties collaborate, share and manage the evolved nuclear knowledge is significant. This paper discusses the approach applied by the national regulatory body to develop the NKM program as a tool to support the regulatory decision and maintain public trust. It highlights the real practice to improve the interactions between knowledge, organization, culture, processes, and employee's competencies.