ManageChatDiscover
66500

Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

For many decades the terrestrial plants are represent an infinitive source of bioactive substances  as well as pharmaceutical components which play a main role in the discovering ,developing and manufacturing of anticancer and antibiotic drugs.Solenostemmaargel is a desert plant widely used in Arabic countries as antispasmodic, anti-inflammatory and anti-rheumatic agent. It also has anti-tumor activity. Aim: the present study was oriented to investigatethe hepato-protective effect of fermentedSolenostemmaargelleave extract (100amg/kg b.wt) and/or low dose γ-radiation (0.5Gy) againsthepatocellular carcinoma (HCC)developedin rats by injection of diethylnitrosamine. Results: the data obtained revealed that thepro-apoptotic agents (caspase 3 and cytochrome c) undergoes significant elevation in HCC rats received plant extract and/or γ-radiation compared to HCC rats.While,the vascular endothelial growth factor (VEGF), hypoxia inducible factor-α (HIF-α)and monocytichemotactic protein-1(MCP-1) were significantly decreased. Also, the activity of cyclooxygenase-2 (COX-2) was significantly decreased. Moreover, the histopathological analysis revealed that a mild improvement .In conclusion, the improvement emerged in HCC rats could be attributed to the potency of extract and/or  γ- radiation by induce apoptosis and reduce angiogenesis.

DOI

10.21608/ajnsa.2019.66500

Keywords

Fermented Solenostemmaargel Extract/ Low Dose γ-Radiation/HCC/ Diethylnitrosamine

Authors

First Name

Asmaa

Last Name

Hassan

MiddleName

-

Affiliation

Department of Radiation Biology, National Center of Radiation Research and Technology, Atomic Energy Authority, Egypt

Email

asmaabubakr98@yahoo.com

City

-

Orcid

-

First Name

S.

Last Name

El-Sonbaty

MiddleName

M.

Affiliation

Department of Radiation Microbiology, National Center of Radiation Research and Technology, Atomic Energy Authority, Egypt

Email

-

City

-

Orcid

-

Volume

53

Article Issue

1

Related Issue

10143

Issue Date

2020-01-01

Receive Date

2019-01-01

Publish Date

2020-01-01

Page Start

234

Page End

242

Print ISSN

1110-0451

Online ISSN

2090-4258

Article File

AJNSA_Volume 53_Issue 1_Pages 234-242.pdf

PDF . 789.6kB

Link

https://ajnsa.journals.ekb.eg/article_66500.html

Detail API

https://ajnsa.journals.ekb.eg/service?article_code=66500

Order

24

Type

Original Article

Type Code

455

Publication Type

Journal

Publication Title

Arab Journal of Nuclear Sciences and Applications

Publication Link

https://ajnsa.journals.ekb.eg/

MainTitle

Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma

Details

Type

Article

Created At

22 Jan 2023