Abstract
Intra-cytoplasmic sperm injection (ICSI) has become an essential procedure in assisted reproductive units for infertile patients. Polycystic ovary syndrome (PCOS) and diabetes are two syndromes with their drawbacks on fertility. Objectives: The aim of this research was to study the impact of the morphological abnormalities of MII oocytes on fertilization rate, embryo quality and pregnancy following ICSI in patients with diabetes, PCOS patients. Patients and methods: This prospective observational study was done on 177 women. MII oocytes with normal or abnormal morphology, fertilization rate, embryo quality, and positive or negative pregnancies were assessed in all patients and compared between the different groups. Results: In the control group the total number of oocyte abnormalities was 146/446 MII oocytes with a percentage of (33%). In the diabetes group the total number of abnormalities in MII oocytes was 231/90 MII oocytes with a percentage of (257%), and in the PCOS the total number of abnormalities was 414/229 abnormalities in the MII oocytes with a percentage of (181%). In diabetic patients despite the higher oocytes abnormalities and the more low quality embryos than in PCOS patients, the pregnancy rate were significantly higher in the diabetes group (59.5%) compared to that in the PCOS group (51.9%),with the highest percentage of pregnancy presented in the control group (83.7%). Conclusion: ICSI outcome was significantly better in diabetic patients when compared to PCOS patients. The best outcome was observed in the control group.