The present study was conducted to compare the effect of nano-selenium (Nano-Se) and sodium selenite (SSe) on growth performance, antioxidative status and blood biochemicalof growing New Zealand White (NZW) rabbits. Total numbers of five weeks old rabbits were divided randomly into three groups (each had 24 of which a half of males and a half of females) were used. The first group was served as a placebo; in groups 2 and 3, each rabbit was intramuscularly injected once a week with 4ml solution of Nano-Se or SSe, respectively. The solution was adjusted to provide 30 µg Se/kg/live body weight. Growth trial lasted for two months. Results demonstrated that rabbits with Nano-Se treatment had showed higher significance in total gain and daily gain weight than SSe and control. Nano-Se and SSe showed low AST and ALT activities than control, with high advantage for SSe. Both Nano-Se and SSe increased significantly GR and TAC activities than the control, the upper hand recorded by Nano-Se. MDA activity was recorded similar trend using Nano-Se with significant decrement than other groups. TC, LDL, VLDL, triglycerides, and phospholipids decreased significantly due to Nano-Se group than the others. Nano-se and SSe recorded higher significantly HDL, and triglycerides and VLDL than control, respectively. T3 and T4 levels were elevated dramatically in Nano-se group, also feed efficiency, feed conversion ratio and daily gain were improved. It can be concluded that Nano-se supplementation caused positive changes in blood constituents which improved growth performance of growing NZW rabbits more than SSe.