Abstract
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women during reproductive age, Women with PCOS show raised Anti-Müllerian hormone (AMH) levels, due to increased number of small antral follicles and granulosa cells, and these may lead to anovulation. Measuring antral follicle count (AFC) and ovarian volume (OV) by ultrasound give insight to the ovarian function. This study was done to investigate the relation between AMH with AFC, OV and different biochemical parameters which determine PCOS. This study was carried out on thirty patients with PCOS as (group 1) compared with fifteen healthy women as control group (group 2). AMH, FBS, Insulin, HOMA/IR, Testosterone, cholesterol, Triglycerides (TG), body mass index (BMI) and hirsutism were measured for all women in both groups. The results revealed that serum level of AMH is significantly higher in PCOS (11.90±4.23ng/ml) than control group (4.36±0.56ng/ml). As regards AFC, there is high significant increase (26.10± 5.49 follicles) in PCOS group versus (9.07 ±1.83 follicles) in control group. Furthermore, the results revealed high significant difference in OV (11.20±2.78ml) in PCOS compared to (6.23±0.73ml) in control. There is significant correlation between AMH, AFC and OV in PCOS, There is high significant correlation between AMH, AFC, OV, BMI testosterone, HOMA/IR, HDL, cholesterol, and TG in both groups. We conclude that there is a tight positive correlation between AMH and AFC and OV.