Chronic kidney disease (CKD) is a worldwide public health problem. Oxidative stress is the causative factor for a wide variety of diseases, including CKD.Medicinal plants used in the management of CKD are effective in renal detoxification and help the effects of dialysis treatment.This study was conducted to investigate the effect of aqueous extract of sage (Salvia Officinal) and marjoram (Origanum Majoranum) on advanced chronic kidney patients under dialysis. The experiment was carried out on sixty patients (40-50 years old), diagnosis based on detailed clinical history, clinical examination and other relevant biochemical investigations.The patients were divided into 6 groups (each group contain 10 CKD patients under treatment with (hemodialysis and regular medical treatment for 3 months)as followed: control patients were treated with regular medical treatment, other patients consumed aqueous extracts of (5g sage, 5g marjoram, 10g sage, 10g marjoram, mixture of 5g sage +5g marjoram) twice today respectively. Results illustrated that the aqueous extract of marjoram or sage are rich in antioxidants components (Phenolic acids, Flavonoids, Oxygenated monoterpenes, Diterpenoids and Triterpenes), antioxidant capacity and phenolic content.Results clarify that glomerular filtration rate (GFR) increased, while erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) significantly decreased (P<0.05) in all treated patients compared to the control group. Malondialdehyde (MDA) decreased and superoxide dismutase (SOD) increased. The mixture of aqueous extracts of marjoram (5g) and sage (5g) recorded the best drink. Therefore, this study recommends the use of the aqueous extracts of marjoram (5g) and sage (5g) in decreasing the oxidative stress and improve kidney health in hemodialysis patients.