The study aimed to investigate the relationship between serum uric acid (SUA) concentration and atherosclerosis. Fourty five adult men aged 40-60 years were volunteers from three different institutions in Cairo. They were divided into 3 equal groups: one group being clinically healthy and normal serum uric acid was taken as control. The second group suffered from hyperlipidemia and hyperuricemia. The third group suffmred from hypermricemia only All groups were subjected to socioeconomic data collection, dietary and anthropometric {weights and heights) assessment, chemical analysis included serum levels of uric acid, lipid profile and platelets count. The results showed that all groups had their requirements from total calories and total proteins but low in carbohydrates. Group II had high fat and purine intake. It also showed positive correlation between serum uric acid and each of protein, fat and purine intake and the highest atherogenic index. Also there was positive correlation between serum uric acid and blood levels of triglycerides and cholesterol and negative correlation with blood platelets. Hence, it is recommended to have balanced diet with reasonable amount of foods rich in purine as prophylactic measure against atherosclerosis.