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Reishi Mushroom (Ganoderma lucidum) Extract Ameliorate Hyperglycemia and Liver/Kidney Functions in Streptozotocin-induced Type 2 Diabetic Rats

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Last updated: 03 Jan 2025

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Subjects

-

Tags

Bioavailability of nutrients and metabolism

Abstract

Diabetes is a metabolic condition characterized by hyperglycemia and insufficient insulin production or activity. Since ancient times, the reishi mushroom (Ganoderma lucidum) has been utilized as a traditional herbal treatment. Aim of the study: investigate the effectiveness of Ganoderma lucidum extract (GLE) to ameliorate hyperglycemia and liver/kidney functions in streptozotocin-induced type 2 diabetic rats. Six groups of adult male Sprague–Dawley rats were formed at random. Group 1: Normal rats with a normal diet. Group 2: Diabetic rats by injection Streptozotocin (STZ) and fed without intervention as a model control group; Groups 3-6: GLE, diabetic rats with intervention groups receiving GLE at doses of 200, 400, 600, and 800 mg/kg BW via oral gavage for 28 days. After GLE intervention, blood samples were tested for changes in hyperglycemia, glycosylated hemoglobin, insulin, liver, and kidney functioning. Results: Within the first two weeks of GLE intervention, blood glucose levels were reduced, and insulin levels in diabetic rats in the GLE group were considerably higher at four weeks than in the positive control group. Furthermore, it was discovered that GLE intervention significantly improved the liver and kidney functioning of diabetic rats. Conclusion: This research suggests that GLE consumption may help reduce blood glucose levels by boosting insulin production. Meanwhile, GLE therapy was linked to a reduction in diabetes problems in type 2 diabetic rats by improving their liver and renal functioning.  

DOI

10.21608/bnni.2021.221596

Keywords

Ganoderma lucidum, weight, Blood Glucose, Glycosylated Hemoglobin, Insulin

Authors

First Name

Samah

Last Name

Elsemelawy

MiddleName

A

Affiliation

Department of Home Economics, Faculty of Specific Education, Tanta University, Tanta, Egypt.

Email

-

City

Tanta

Orcid

-

First Name

Mai

Last Name

Gharib

MiddleName

A

Affiliation

Department of Nutrition and Food Science, Faculty of Home Economics, Minoufiya University, Shebin El-Kom, Egypt

Email

-

City

Shebin El-Kom

Orcid

-

First Name

Yousif

Last Name

Elhassaneen

MiddleName

A

Affiliation

Department of Nutrition and Food Science, Faculty of Home Economics, Minoufiya University, Shebin El-Kom, Egypt

Email

-

City

Shebin El-Kom

Orcid

-

Volume

57

Article Issue

1

Related Issue

30309

Issue Date

2021-06-01

Receive Date

2021-04-24

Publish Date

2021-06-01

Page Start

74

Page End

107

Print ISSN

1110-0974

Online ISSN

2537-0987

Article File

BNNI_Volume 57_Issue 1_Pages 74-107.pdf

PDF . 1.5MB

Link

https://bnni.journals.ekb.eg/article_221596.html

Detail API

https://bnni.journals.ekb.eg/service?article_code=221596

Order

4

Type

Original Article

Type Code

442

Publication Type

Journal

Publication Title

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt

Publication Link

https://bnni.journals.ekb.eg/

MainTitle

Reishi Mushroom (Ganoderma lucidum) Extract Ameliorate Hyperglycemia and Liver/Kidney Functions in Streptozotocin-induced Type 2 Diabetic Rats

Details

Type

Article

Created At

22 Jan 2023