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196206

Potential Protective Effects of Ganoderma lucidum Powder against Carbon Tetrachloride Induced Liver Disorders in rats: Biological, Biochemical and Immunological Studies

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Bioavailability of nutrients and metabolism

Abstract

Liver is the main organ in the body for intense metabolism and excretion. A large number of chemicals and medicines/drugs used routinely in daily lives can cause disorders and possibly liver disease. The aim of exploring some aspects related to the potential hepatoprotective activity of Ganoderma lucidum versus carbon tetrachloride (CCl4) intoxication in rat liver. When compared with the normal group rats, the CCl4 treated rats showed significant (p≤0.05) decreased in different biological parameters. Also, biochemical parameters such liver enzymes activities were significant (p≤0.05) elevation when compared with the normal group rats. For immunological parameters, Alb was significant (p≤0.05) decreased by the rate of -29.44 and TNF-α increased by 93.28%. This also coincided with an imbalance in the oxidants/antioxidants status in the blood, which was represented by a decrease in the level of antioxidants and a high level of oxidants. All of those parameters were indicating the liver injury by CCl4. Whereas animal treated/fed with Ganoderma lucidum powder (GLP) showed significant (p≤0.05) improvements in all previous status biomarkers indicating the protection against hepatic cell damage. A positive dose - response was recorded between the concentrations of GLP applied and the level of improvement noticed in all measured markers. In conclusion, GLP was effective in protecting against CCl4-induced liver disorders. Present study recommended like of that algae powder by a concentrations up to 5% (w/w), amount to be included in daily diets, drinks and food supplementation after trial study on volunteer human.

DOI

10.21608/bnni.2020.196206

Keywords

Ganoderma lucidum, powder, biomarker of biological and immunity

Authors

First Name

Sara

Last Name

Sayed Ahmed

MiddleName

A.

Affiliation

Department of Home Economics, Faculty of Specific Education, Port Said University, Port Said;

Email

-

City

Port Said

Orcid

-

First Name

Nahed

Last Name

Abd Elalal

MiddleName

S.

Affiliation

Department of Home Economics, Faculty of Specific Education, Zagazig University, Zagazig;

Email

-

City

Zagazig

Orcid

-

First Name

Yousif

Last Name

Elhassaneen

MiddleName

A

Affiliation

Department of Nutrition and Food Science, Faculty of Home Economics, Minoufiya University, Shebin El-Kom, Egypt

Email

yousif12@hotmail.com

City

Minoufiya

Orcid

-

Volume

56

Article Issue

2

Related Issue

25093

Issue Date

2020-12-01

Receive Date

2020-09-26

Publish Date

2020-12-01

Page Start

99

Page End

132

Print ISSN

1110-0974

Online ISSN

2537-0987

Article File

BNNI_Volume 56_Issue 2_Pages 99-132.pdf

PDF . 1.6MB

Link

https://bnni.journals.ekb.eg/article_196206.html

Detail API

https://bnni.journals.ekb.eg/service?article_code=196206

Order

4

Type

Original Article

Type Code

442

Publication Type

Journal

Publication Title

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt

Publication Link

https://bnni.journals.ekb.eg/

MainTitle

Potential Protective Effects of Ganoderma lucidum Powder against Carbon Tetrachloride Induced Liver Disorders in rats: Biological, Biochemical and Immunological Studies

Details

Type

Article

Created At

22 Jan 2023