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190313

Protective Effect of Nettle and Olive Leaves on Hyperlipidemia in Experimental Rats

Article

Last updated: 03 Jan 2025

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Tags

Bioavailability of nutrients and metabolism

Abstract

D yslipidemia is a major contributor to atherosclerotic cardiovascular disease. Recently, World Health Organization (WHO) reported that cardiovascular diseases (CVD) account for 46% of ever all mortality in Egypt. So that; the present study investigated, the protective effect of nettle and olive leaves on hyperlipidemia in experimental rats. Thirty six male albino rats weighing 130 ± 20 g used in this study and  divided into equal six groups ( 6 rats each),the first  kept as anegative control group (-ve) received basal diet  throughout the experiment period, while  the second  was the (+ve) control group which fed on hyperlipidemic diet for four weeks, while the four others groups given hyperlipidemic diet  supplemented with   nettle leaves  (5%) ,( 10 %)  and olive leaves(5 %), (10%)   respectively for four weeks (astreatment groups ) .The chemical composition and phenolic compounds of  both leaves were done .  At the end of the experiment, biological data were calculated; blood samples were taken to biochemical analysis. In addition, histopathological examination was done. The results revealed that hyperlipidemic diet  in the (+ve) control group increased body weight gain ,relative organ weight, serum lipid profile, Malondialdhyde (MDA), liver enzymes and serum glucose, decreased in serum HDL-C, serum Superoxide Dismutase (SOD),  and Glutathione Peroxidase (GPx)  .  All treated groups with two leaves showed improvement previously parameters compared with positive control group. In conclusion, the consumption of nettle and olive leaves could be used for improving lipid profile, liver function and protect from hyperlipidemia in experimental rats. 

DOI

10.21608/bnni.2020.190313

Keywords

lipid profile- nettle - olive - leaves, antioxidant enzymes- liver function

Authors

First Name

Aya

Last Name

Mohamed Anies

MiddleName

Salah Elden

Affiliation

Nutrition and Food Science Dept., Faculty of Home Economics, Al-Azhar University, Egypt

Email

-

City

TanTa

Orcid

-

First Name

Suzan

Last Name

Saad

MiddleName

A.E.

Affiliation

Nutrition and Food Science Dept., Faculty of Home Economics, Al-Azhar University, Egypt

Email

-

City

Tanta

Orcid

-

First Name

Suzan

Last Name

Ibraheim

MiddleName

S.

Affiliation

Nutrition and Food Science Dept., Faculty of Home Economics, Al-Azhar University, Egypt

Email

suzansamiibraheim@azhar.edu.eg

City

Tanta

Orcid

-

Volume

56

Article Issue

2

Related Issue

25093

Issue Date

2020-12-01

Receive Date

2020-11-15

Publish Date

2020-12-12

Page Start

69

Page End

98

Print ISSN

1110-0974

Online ISSN

2537-0987

Article File

BNNI_Volume 56_Issue 2_Pages 69-98.pdf

PDF . 1.8MB

Link

https://bnni.journals.ekb.eg/article_190313.html

Detail API

https://bnni.journals.ekb.eg/service?article_code=190313

Order

3

Type

Original Article

Type Code

442

Publication Type

Journal

Publication Title

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt

Publication Link

https://bnni.journals.ekb.eg/

MainTitle

Protective Effect of Nettle and Olive Leaves on Hyperlipidemia in Experimental Rats

Details

Type

Article

Created At

22 Jan 2023