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164215

Role of Oxidant/Antioxidant Status in the Pathogenesis of Iron-Deficiency Anemia: Case Study on Children of Qalyubiyya and Minoufiya Governorates, Egypt

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical trials and cohort studies, with an emphasis on methods for assessing dietary exposures

Abstract

Iron- deficiency anemia (IDA) is anemia due to insufficient iron. It is one of the major causes of morbidity and mortality worldwide affecting people of all ages in both developed and developing countries. The present study aims to investigate the role of oxidative/antioxidant status in the pathogenesis of IDA through a case study on children of Qalyubiyya and Minoufiya Governorates, Egypt. 119 with IDA and 150 healthy control, boys and girls, infants and young children, aged zero months to 6 years, were selected for the study from Rural Health Units and Maternity and Child Care Centers, Qalyubiyya and Minoufiya Governorates, Egypt. Based on hematological and biochemical analysis, the mean hemoglobin (Hb) level, mean corpuscular volume (MCV), reticulocyte hemoglobin content, serum iron and serum ferritin were significantly lower in infants and young children with IDA than healthy control. The opposite direction was observed for the red blood cell distribution width (RDW). The antioxidant defense system parameters including [enzymes (glutathione peroxidase, GSH-Px; glutathione reductase, GSH-Rd; superoxide dismutase, SOD and catalase, CAT) activities and none-enzymatic levels (glutathione, GSH and vitamins A, C and E)] of infants and young children with IDA were significantly (P≤0.05) lower. While the oxidative stress parameters thiobarbituric acid reactive substances, TBARS and nitric oxide, NO2 were significantly higher than the control group. In conclusion, oxidant/antioxidant status may play a role in the Pathogenesis of Iron-Deficiency Anemia.

DOI

10.21608/bnni.2021.164215

Keywords

Hematologic markers- antioxidant (enzymes, vitamins) - oxidative stress

Authors

First Name

Eman

Last Name

Mehram

MiddleName

B

Affiliation

Department of Home Economics, Faculty of Specific Education, Benha University,

Email

-

City

Benha

Orcid

-

First Name

Sara

Last Name

Ahmed

MiddleName

A.

Affiliation

Department of Home Economics, Faculty of Specific Education, Port Said University

Email

-

City

Port Said

Orcid

-

First Name

Yousif

Last Name

Elhassaneen

MiddleName

A

Affiliation

3Department of Nutrition and Food Science, Faculty of Home Economics, Minoufiya University, Shebin El-Kom, Egypt

Email

-

City

Minoufiya

Orcid

-

Volume

55

Article Issue

1

Related Issue

23814

Issue Date

2020-06-01

Receive Date

2021-04-12

Publish Date

2020-06-01

Page Start

39

Page End

71

Print ISSN

1110-0974

Online ISSN

2537-0987

Article File

BNNI_Volume 55_Issue 1_Pages 39-71.pdf

PDF . 1.4MB

Link

https://bnni.journals.ekb.eg/article_164215.html

Detail API

https://bnni.journals.ekb.eg/service?article_code=164215

Order

2

Type

Original Article

Type Code

442

Publication Type

Journal

Publication Title

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt

Publication Link

https://bnni.journals.ekb.eg/

MainTitle

Role of Oxidant/Antioxidant Status in the Pathogenesis of Iron-Deficiency Anemia: Case Study on Children of Qalyubiyya and Minoufiya Governorates, Egypt

Details

Type

Article

Created At

22 Jan 2023