Tsativa seeds (NSS) and their combination on hyperuricemia. Thirty male albino rats assigned to five groups (n=6). The first these fed on the standard diet as normal control rats. The other rats (n=24), received a basal diet including a 20g /kg diet potassium oxonate to create hyperuricemia. Then ill rats divided into four groups. The hyperuricemic control group and three groups treated with added to their diet 10% QS; 4% NSS and mix from10% QS plus 4%NSS respectively. After that, the researcher calculated the biological status and estimated biochemical analysis. The results appear that high uric acid groups, in which feeding remedy diets showed no significant variation in biological parameters compared with the normal rats. The same groups indicated a significant improvement in renal function when compared with the injury group. Likewise, rising kidney tissues antioxidant status “superoxide dismutase; catalase and glutathione transferase" and decrease "malondialdehyde and interleukin-1 (IL-6)". Also, the mixture diet increased antioxidant activity. This study concluded that QS and NSS may improve kidney function and may reduce oxidative stress. This article recommended that special meals of hyperuricemic patients supplemented by a blend of QS and NSS.