Background:
Polycystic Ovary Syndrome (PCOS) is a typical Endocrine Syndrome in women. It has 5 to 10% prevalence.
Objective:
This study aims to investigate the Bisphenol-A (BPA) as a marker for PCO with a high levels in women with PCO , and to evaluate the ability of urinary noninvasive method for the detection of BPA.
The secondary outcomes from our study were to correlate the BPA level with fasting insulin levels, and free testosterone in women with PCO, and if there is association with infertility.
Patients and methods:
A cross sectional study was made in 2 groups (group 1; women with PCO (110 women) and group 2; non PCOS women (110 women) .
The intervention:
Detection of urinary Bisphenol-A was made by using HPLC.
The measurement of serum FSH, LH, Fasting insulin and free testosterone levels was performed.
Results:
Women with PCO had a significant high urinary Bisphenol A level and more than the control group (3439.05 ± 2118.25 μg /mL and. 813.84 ± 584.78 μg /mL, P<0.001, respectively).
A positive correlation between the urinary Bisphenol-A levels and the serum LH was determined. On contrary, there is a negative correlation between the urinary Bisphenol-A and the levels of the serum FSH.

Conclusion:
The correlation analysis model among the biochemical markers has shown a significant positive association between urinary BPA concentration and serum LH as well as the free testosterone and fasting insulin (P<0.001). The urinary method for Bisphenol-A level detection can be used for women, and is taken as an easy noninvasive method. There is a positive correlation between elevated Bisphenol-A levels and PCO and infertility. Thus, avoiding elevation of Bisphenol-A levels in the environment could provide a good impact on reproductive health. As it is not yet established whether the observed association suggests an etiological factor or whether the endocrine pattern associated with PCOS alters the storage and clearance patterns of BPA and causing elevated BPA, So the present study reported that there is a significant positive association between BPA and PCOS .