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194016

HPLC DETECTION OF SERUM AND URINARY PARAPHENYLENE DIAMINE (PPD) LEVEL AND ITS METABOLITES IN RELATION TO CARDIAC TOXICITY

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

• Cardiac toxicity

Abstract

Hair dye poisoning is an emerging big problem in Upper Egypt. The main component of hair dye causing toxicity is para-phenylenediamine (PPD). Ingestion of PPD could be accidental or suicidal. After oral intake it is metabolized in the liver into N-mono- (MAPPD) and N,N′- diacetylated (DAPPD) metabolites. Tissue damage after PPD ingestions occurs due to increased levels of free radical and oxidative stress that deplete tissue glutathione. Cardiac toxicity is a complication of PPD poisoning. It could be manifested by hypotension, different patterns of arrhythmia; in addition, myocarditis and elevated cardiac biomarkers were also found. Serum and urinary levels of PPD, N-acetyl-p-phenylenediamine (MAPPD) and N--diacetyl-p-phenylenediamine (DAPPD) were measured by HPLC. A prospective cohort study was planned to determine relation between the serum and urinary PPD, N-acetyl-p-phenylenediamine (MAPPD) and N,on -diacetyl-p-phenylenediamine (DAPPD) levels with cardiac manifestations of poisoned patient. Forty patients completed the diagnosis to have acute poisoning following hair dye ingestion. PPD and its metabolite concentrations did not show any significant correlation with the prevalence of cardiac toxicity and could not predict its occurrence among studied patient (p-value< .05)

DOI

10.21608/ejfsat.2020.32659.1153

Keywords

Key words: Hair dye, PPD, Cardiac

Authors

First Name

marwa

Last Name

mohamed

MiddleName

issak

Affiliation

department of forensic and clinical toxicology cairo university

Email

missak1978@hotmail.com

City

cairo

Orcid

0000-0002-8026-6858

First Name

mona

Last Name

aly

MiddleName

mohamed

Affiliation

department of forensic medicine and clinical toxicology cairo university

Email

mona_mohamed_aly@yahoo.com

City

cairo

Orcid

000-0002-0792-8317

First Name

Sara

Last Name

Hamed

MiddleName

-

Affiliation

Forensic &amp;amp; Clinical Toxicology Department, Faculty of medicine, Cairo University

Email

snasrtaha@cu.edu.eg

City

Cairo

Orcid

0000-0002-0777-7678

First Name

fatma

Last Name

Gawish

MiddleName

-

Affiliation

Luxor international hospital

Email

fatmagawish985@yahoo.com

City

Cairo

Orcid

-

First Name

hanan

Last Name

zaghla

MiddleName

elsayed

Affiliation

department of critical medicine cairo university

Email

hananzaghla410@gmail.com

City

Cairo

Orcid

-

First Name

mahmoud

Last Name

khaled

MiddleName

-

Affiliation

department of critical care cairo university

Email

noricu@yahoo.com

City

-

Orcid

-

First Name

Samah

Last Name

ibrahim

MiddleName

fathy

Affiliation

department of forensic medicine and toxicology princess Noura University Saudi Arabia

Email

samahibrahim@yahoo.com

City

Saudi Arabia

Orcid

0000-0002-2824-3296

First Name

AHMED

Last Name

ELSAWY

MiddleName

SAMIR

Affiliation

department of critical care cairo university

Email

ahmed_s_elsawy@yahoo.com

City

Cairo

Orcid

-

Volume

21

Article Issue

3

Related Issue

27484

Issue Date

2021-09-01

Receive Date

2020-06-25

Publish Date

2021-09-01

Page Start

31

Page End

42

Print ISSN

1687-0875

Online ISSN

2535-1915

Article File

EJFSAT_Volume 21_Issue 3_Pages 31-42.pdf

PDF . 473.5kB

Link

https://ejfsat.journals.ekb.eg/article_194016.html

Detail API

https://ejfsat.journals.ekb.eg/service?article_code=194016

Order

4

Type

Original Article

Type Code

429

Publication Type

Journal

Publication Title

The Egyptian Journal of Forensic Sciences and Applied Toxicology

Publication Link

https://ejfsat.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023