Human skeletal remains identification is crucial in forensic investigations, so the differentiation of the sex of a human bone is a significant initial stage for estimation of age and height of any unknown skeletal bone. AIM: The present study was designed to compare and evaluate the role of piriform and orbital aperture measurements in sex discrimination by using computed tomography in a sample of Egyptian population. SUBJECTS AND METHODS: This study was done by using 89 computed tomography (CT) images of the piriform and orbital bone obtained from the Radiology Department, Menoufia University Hospital for numbers of males' and females' patients (43 of them were for males and 46 were for females) aged from 20 to 70 years. Where morphometric measurements of piriform and orbital aperture were obtained. RESULTS: This study was conducted on 89 CT images; 43 of them were for males representing 48.3% with a mean age of 47.44± 16.54 years, while 46 cases were for females representing 51.7% with a mean age 44.52 ±15.56 years. A highly significant difference (p < 0.01) was obvious between both sex for left orbital width, right, and left orbital area with greater values in males. Measurements of piriform aperture (PA) in this study as length, width, and area showed that males presented with significantly greater mean values than females. Besides that, the Piriform area was the best sex discriminant as it had the highest sensitivity 93%, specificity 85%, and accuracy 88.7% at a cut off equal 64 mm or more suggesting males (p < 0.001). CONCLUSION: Sex determination of human skeletons is important in forensic and anthropological research. The present study revealed that piriform and orbital aperture have sexual dimorphism and can be helpful in sex discrimination especially the piriform area, which had the best accuracy in this study, as it had highest sensitivity 93%, specificity 85% and 88.7% accuracy.