Egypt like other developing countries use pesticides widely to increase crops production and prevent spread of vector-borne diseases. However, pesticides poisoning is considered as a public health problem as it is associated with high morbidity and mortality. Objectives: evaluation the red cell distribution width (RDW), neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) as prognostic markers in acutely pesticide-poisoned patients. Methodology: eighty patients with acute pesticide poisoning who admitted to Toxicology Unit of Emergency Hospital, Tanta University, were classified into three groups according to their outcome. Three mL of venous blood were drawn for performing complete blood count (CBC), and were analyzed by hematology analyzer machine. The RDW, NLR, and PLR were assessed. Results: Patients of group (3) had the significant highest total WBCs, neutrophils and platelets counts (P