ABSTRACT Background: Road traffic accidents are a major cause of disability and death globally. The problem is increasing in developing countries. Objectives: This study was designed to study cases of road traffic accidents (RTA) treated atMenoufia University Hospital (MUH) in Menoufia, Egypt, in the period from first of July 2016 to end of June 2017. Patients and Methods: Data from 2080 cases of RTAs were analyzed. Data included socio-demographic information, type of vehicle, type of victims, type of injuries, and outcome of these cases. Results: The highest represented age group was from 15 to 30 year (43.8%). Majority of cases were males (81.6%). 64.1% were from rural areas. Majority of cases were due to motor car accidents (62.4%). Pedestrians were the most common victims (54.2%) followed by passengers (31.4%).75.9% of the victims suffered from abrasions and/or contusions and 48.6% from lacerations. According to legal classification more than half of the cases suffered from dangerous injuries (53.3%), 37.4% simple and only 9.3% had fatal injuries. Of the survivors, 79.6% were cured and 9% were cured with permanent infirmity. Conclusion: Road traffic accidents are definitely a serious problem in our setting and lead to a raising morbidity and mortality rates. Substances of abuse are a probable risk factor. Recommendations: RTAs need effective rapid preventive measures to decrease its incidence. Strict control on substances of abuse is also needed. Keywords: Road, Traffic, Accidents, Injury, Motor.