ABSTRACT The ability to extract DNA and PCR amplification from biological stains is a key element in forensic genetics. Attempts to remove blood stains using different types of cleaning methods represent a routinely faced forensic problem. Objective: This work was done to evaluate the effect of some cleaning products on the quantity and quality of extracted DNA from bloodstained cloth. Methods: Blood samples were applied to cotton and silk cloth. After drying, the cloth was subjected to the effect of some cleaning products {Clorox (bleach), Dettol (disinfectant), Persil (detergent), Vanish (stain remover) and distilled water}. DNA extraction and PCR amplification were done to estimate the quantity and quality of extracted DNA by spectrophotometer and gel electrophoresis. Results: There was significant reduction in amount of extracted DNA from silk compared to cotton cloth in all samples including controls. Detectable amounts of DNA could be recovered after amplification by PCR with all types of cleaning agents. Cleaning with Vanish resulted in most significant decrease in recovered DNA amount, while cleaning with Clorox resulted in highest recovery of DNA in both cotton and silk cloth. Gel electrophoresis showed that Clorox, Persil and distilled water had no effect on quality of extracted DNA compared to control samples in cotton cloth, while Vanish and Dettol had the most degraded effect. In silk cloth the quality of DNA was affected in all samples mostly with Vanish and Persil. Conclusion: DNA could be recovered from cloth after exposure to different types of cleaning products. Key words: Bloodstains, Cleaning products, DNA.