The safety of monosodium glutamate (MSG) usage has generated much controversy locally and globally. MSG is known to affect the structure and function of male reproductive system as well as fertility. The aim of the present work was to study the toxic effect of MSG on reproductive system of adult male albino rats and to determine the possibility to reverse this effect using curcumin and propolis. Seventy sexually mature male albino rats were used for this study and divided into 7 groups. The first 3 were control groups administered (distelled water, curcumin, and propolis), the 4th group was the experimental and administered MSG at a dose of 4 g/kg body weight for 6ws, the 5 th and 6th groups, MSG was co-administered with curcumin or propolis at the doses of 10 mg, and 50 mg/kg body weight respectively and the 7th group received combination of MSG, curcumin and propolis. It was found that MSG has adverse impacts on male rat reproduction including decrease testicular weight, with histological structure alternation, decrease sperm count and plasma level of testosterone and luteinizing hormone (LH). Coadministration of curcumin and propolis either separately or combined ameliorate these effects where testicular weight and structure of seminiferous tubules with their lumens full of sperms were regained compared to MSG treated animals. Sperm count; testosterone and LH levels were improved.