Landscape genomic studies can help define the role of geography and ecology in the clinical presentation of
parasitic diseases, and consequently provide the choice for accurate diagnosis, novel therapeutic regimens,
and effective strategies for control and elimination. In this regard, RNA interference technology combined
with phenotypic studies can pinpoint exactly the incriminated molecules and/or pathways that might
help in identification of novel drug targets and promising vaccine candidates. Previously, we discussed the
applications of omics and bioinformatics in diagnosis, treatment, and control of malaria, one of the major
health problems and causes of death worldwide[1]. In the present part, we intend to unravel the complexity
of genomic and post genomic implications in the pathogenesis of helminthic diseases aiming to develop and
design new therapeutic drugs and/or protective vaccines against helminths diseases.