Parasitic diseases have significant global economic, environmental, and public health impacts. In recent
years, stem cells therapy has become a very promising and advanced scientific research topic. Since stem
cells are the primary, unspecialized mother of all cells, they have the ability to differentiate into specialized
cells. Besides, they have a remarkable potential to develop into many different cell types in the body to replace
the damaged tissues. Recently, researchers experimentally investigated the application of these cells to treat
parasitic diseases such as schistosomiasis, malaria, trypanosomiasis, leishmaniasis and toxoplasmosis with
improvement of the function of the involved tissue and organs. This review summarized the up-to-date
application of stem cell technology for treatment and/or protection against parasitic diseases. We aimed to
highlight how these approaches affected the parasite–host interactions and contribute to the identification of
novel targets for therapies and vaccines.