Chronic infections with microbes, such as viruses, bacteria and parasites contribute to a considerable
proportion of the worldwide burden of cancer cases. Helminthic infections cause a relatively small proportion
of the infection-related cancers, but the higher exposure to the worldwide helminth infections presents an
importance of health problem. Notably, these infections are a preventable cause of cancer that highlights
the prevention and control as well as health education in endemic areas to reduce infection levels and
consequently reduce the risk of development of infection-related cancers. This review intends to spotlight the
association of certain helminth infections with human malignancy and to focus on their innovative pathways
of causing neoplasia.