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210898

Perceptions on therapeutic modalities regarding the virulence and immunity of cutaneous leishmaniasis

Article

Last updated: 22 Jan 2023

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Abstract

Despite the wide variety of Leishmania spp. virulence, the present repertoire of drugs has limited effects, showing increased resistance. The effect depends on host immune factors which differ between immunocompetent and immunocompromised patients, and among various clinical forms of the disease. Recently, metallocomplexes have been increasingly shown to be potent delivery systems for conventional treatments. Additionally, lasers were suggested as an efficacious treatment tool due to their potentials in the clinical applications and resolution of the disease. This review suggests that the promising leishmanicidal activity of the metallocomplexes and laser treatment comprise a new hopeful alternative in the search for definitive cutaneous leishmaniasis (CL) cure.

DOI

10.21608/puj.2021.95583.1132

Keywords

: cutaneous leishmaniasis, leishmanial drug resistance, laser, metallocomplexes, virulence factors

Authors

First Name

Enas

Last Name

El Saftawy

MiddleName

-

Affiliation

Departments of Medical Parasitology, Faculties of Medicine, Cairo Universities, Armed Forces College of Medicine, Cairo, Egypt

Email

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City

-

Orcid

-

First Name

Ahmed

Last Name

Hamed

MiddleName

-

Affiliation

Departments of Medical Parasitology, Faculties of Medicine, Armed Forces College of Medicine , Cairo, Egypt

Email

ahmedhamed1994234@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Sameh

MiddleName

-

Affiliation

Departments of Medical Parasitology, Faculties of Medicine, Armed Forces College of Medicine, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Rania

Last Name

Sarhan

MiddleName

-

Affiliation

Departments of Medical Parasitology, Faculties of Medicine, Ain Shams Universities, Armed Forces College of Medicine , Cairo, Egyp

Email

raniasarhan99@gmail.com

City

-

Orcid

0000-0002-7174-1688

Volume

14

Article Issue

3

Related Issue

29661

Issue Date

2021-12-01

Receive Date

2021-09-12

Publish Date

2021-12-01

Page Start

229

Page End

243

Print ISSN

1687-7942

Online ISSN

2090-2646

Article File

PUJ_Volume 14_Issue 3_Pages 229-243.pdf

PDF . 1.1MB

Link

https://puj.journals.ekb.eg/article_210898.html

Detail API

https://puj.journals.ekb.eg/service?article_code=210898

Order

2

Type

Review Article

Type Code

430

Publication Type

Journal

Publication Title

Parasitologists United Journal

Publication Link

https://puj.journals.ekb.eg/

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Article

Created At

22 Jan 2023