Opportunistic parasites are commonly linked with immunocompromised individuals due to weakness in
their immune system. Alteration in their cellular and humoral responses leads to hindrance of T and B
lymphocytes from efficiently acting against opportunistic pathogens. Accordingly, immunocompromised
patients present increased susceptibility to different microorganisms including viral, bacterial, fungal, and
parasitic infections. Several conditions are commonly associated with host immune system impairment.
Among them enrolled in the present review were malignancy, chronic liver diseases, diabetes mellitus,
renal failure, organ transplantation, and inflammatory bowel disease. The most common reported
opportunistic parasites include species of Cryptosporidium, Blastocystis, and Microsporidium, as well as T.
gondii, C. cayetanensis, I. belli, and S. stercoralis. The objective of the present systematic review is to increase
awareness concerning opportunistic parasitosis among Egyptian immunocompromised individuals from
2010 to 2020 with particular reference to their relative detection rates and risk factors of infection.