ManageChatDiscover
28757

The Outcomes of Mesenchymal Stem Cells Therapy for Experimental Toxoplasmosis

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Protozoology

Abstract

Background: Toxoplasmosis is considered of the widest spread parasitic infections that affects approximately one third of human population. The formation of resident tissue cysts in chronically infected hosts is a challenge; none of the available drugs is capable of eradicating encysted forms of the parasite. It could be disastrous in immunosuppression due to reactivation of the dormant infection. The application of stem cells as promising therapy was tried in some parasitic diseases.
Objective: In this work, stem cells therapy was investigated as a therapeutic line in treatment of murine toxoplasmosis.
Materials and Methods: Parasitological, histopathological and immunohistochemical studies were performed to investigate the curable role of Bone Marrow Mesenchymal Stem Cells (BM MSCs).
Results: The outcomes revealed high significant decrease of the number and size of brain tissue cysts on combining BM MSCs with spiramycin, pyrimethamine and folinic acid. The tested group by BM MSCs as mono-theraputic line of treatment showed poor curable role, as cleared by the results of liver, spleen, eye and brain tissues studies; some improvement was noticed by the recruitment of CD8+ that was cleared by the immunohistochemical study of brain and spleen sections.
Conclusion: BM MSCs alone have a poor therapeutic role, otherwise combined with spiramycin, pyrimethamine and folinic acid for treatment of toxoplasmosis.

DOI

10.21608/puj.2019.7541.1030

Keywords

Bone marrow mesenchymal stem cells, immunosuppression, Pyrimethamine, MSCs, Spiramycin, Toxoplasmosis

Authors

First Name

Samia

Last Name

Etewa

MiddleName

El-Sayed

Affiliation

Medical Parasitology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt

Email

drsamiaetewa@hotmail.com

City

Zagazig

Orcid

-

First Name

Abd-Allah

Last Name

Al-Hoot

MiddleName

Al-Sayed

Affiliation

Zoology Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt

Email

a.alhoot@hotmail.com

City

Zagazig

Orcid

-

First Name

Shimaa

Last Name

Abdelmoaty

MiddleName

Mohamed

Affiliation

Zoology Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt

Email

smabdalmattiy@science.zu.edu.eg

City

Zagazig

Orcid

-

First Name

Samira

Last Name

Mohammad

MiddleName

Metwally

Affiliation

Medical Parasitology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt

Email

samirametwally1971@gmail.com

City

Zagazig

Orcid

-

First Name

Howayda

Last Name

Moawad

MiddleName

Said Fouad

Affiliation

Medical Parasitology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt

Email

drhowaydasaid@gmail.com

City

Zagazig

Orcid

0000-0002-4815-5576

First Name

Mohamed

Last Name

Sarhan

MiddleName

Hassan

Affiliation

Medical Parasitology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt

Email

drsarhan@gmail.com

City

Zagazig

Orcid

0000-0002-5070-3922

First Name

Sara

Last Name

Abd El-Rahman

MiddleName

Ahmed

Affiliation

Medical Parasitology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt

Email

sarameram@yahoo.com

City

Zagazig

Orcid

-

First Name

Mahmoud

Last Name

El-Shafey

MiddleName

Abd El-Aaty

Affiliation

Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt

Email

mahmoudshafey2017@gmail.com

City

Zagazig

Orcid

-

First Name

Eman

Last Name

Abd El-Monem

MiddleName

Zakaria

Affiliation

Zoology Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt

Email

ema_8410@yahoo.com

City

Zagazig

Orcid

-

Volume

12

Article Issue

1

Related Issue

5338

Issue Date

2019-04-01

Receive Date

2019-01-23

Publish Date

2019-04-01

Page Start

34

Page End

44

Print ISSN

1687-7942

Online ISSN

2090-2646

Article File

PUJ_Volume 12_Issue 1_Pages 34-44.pdf

PDF . 560.2kB

Link

https://puj.journals.ekb.eg/article_28757.html

Detail API

https://puj.journals.ekb.eg/service?article_code=28757

Order

6

Type

Original Article

Type Code

426

Publication Type

Journal

Publication Title

Parasitologists United Journal

Publication Link

https://puj.journals.ekb.eg/

MainTitle

The Outcomes of Mesenchymal Stem Cells Therapy for Experimental Toxoplasmosis

Details

Type

Article

Created At

22 Jan 2023