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22884

A potential prophylactic strategy of anti-schistosomal immunization using nanotechnology in murine models

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Last updated: 22 Jan 2023

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Abstract

Background:The emergence of chemotherapy resistant schistosomes necessitates finding new prophylaxis strategies based on immunization by using a modified vaccine candidate. Objective: To assess thepotential of an anti-schistosomal vaccine modified by nanotechnology. Materials and Methods: Soluble adult worm antigen preparation (SWAP) either crude or/and loaded on chitosan nanoparticles (CSNPs)were used. The anti-schistosomal impact was assessed in terms of stools egg count,worm burden and ultrastructural studyof juvenile and adult schistosomes. Results:Chitosan nanoparticles potentiated SWAP efficacy to exceed the impact of crude SWAP.The combination of SWAP loaded on CSNPs and crude SWAP showed the best immunization effects regarding adult worm number andfecundity,as well as morphological and tegumental distortion of juvenile than adult stages. Conclusion:Modified SWAP on CSNPs gave better results in anti-schistosome immunization thancrude SWAP.Immunization by combining different antigens gave the best results.

DOI

10.21608/puj.2018.6072.1023

Keywords

Chitosan nanoparticles, Immunization, schistosomes, SWAP, ultrastructural study

Authors

First Name

Samia

Last Name

Etewa

MiddleName

-

Affiliation

Departments of Medical arasitology,Faculties of Medicine and Science, Zagazig University, Zagazig 44519, Egypt

Email

drsamiaetewa@hotmail.com

City

-

Orcid

-

First Name

Abd-Allah

Last Name

Al-Hoot

MiddleName

-

Affiliation

Departments of Medical Zoology Faculties of Medicine and Science, Zagazig University, Zagazig 44519, Egypt

Email

a.alhoot@hotmail.com

City

-

Orcid

-

First Name

Hesham

Last Name

Sharaf

MiddleName

-

Affiliation

Departments of Medical Zoology Faculties of Medicine,and Science, Zagazig University, Zagazig 44519, Egypt

Email

sharaf_hesham@yahoo.com

City

-

Orcid

-

First Name

Samira

Last Name

Mohammad

MiddleName

-

Affiliation

Departments of Medical Parasitology ,Faculties of Medicine and Science, Zagazig University, Zagazig 44519, Egypt

Email

samirametwally1971@gmail.com

City

-

Orcid

-

First Name

Howayda

Last Name

Moawad

MiddleName

-

Affiliation

Departments of Medical Parasitology,, Faculties of Medicine and Science, Zagazig University, Zagazig 44519, Egypt

Email

drhowaydasaid@gmail.com

City

-

Orcid

0000-0002-4815-5576

First Name

Mohamed

Last Name

Sarhan

MiddleName

-

Affiliation

Departments of Medical Parasitology , Faculties of Medicine and Science, Zagazig University, Zagazig 44519, Egypt

Email

drsarhan@gmail.com

City

-

Orcid

0000-0002-5070-3922

First Name

Mahmoud

Last Name

El-Shafey

MiddleName

-

Affiliation

Departments of Clinical Pathology,Faculties of Medicine and Science, Zagazig University, Zagazig 44519, Egypt

Email

mahmoudshafey2017@gmail.com

City

-

Orcid

-

First Name

Huda

Last Name

Senosy

MiddleName

-

Affiliation

Departments of ,Zoology,Faculties of Medicine and Science, Zagazig University, Zagazig 44519, Egypt

Email

hudasenosy.hs@gmail.com

City

-

Orcid

-

Volume

11

Article Issue

3

Related Issue

4311

Issue Date

2018-12-01

Receive Date

2018-12-26

Publish Date

2018-12-01

Page Start

162

Page End

174

Print ISSN

1687-7942

Online ISSN

2090-2646

Article File

PUJ_Volume 11_Issue 3_Pages 162-174.pdf

PDF . 716.6kB

Link

https://puj.journals.ekb.eg/article_22884.html

Detail API

https://puj.journals.ekb.eg/service?article_code=22884

Order

7

Type

Original Article

Type Code

426

Publication Type

Journal

Publication Title

Parasitologists United Journal

Publication Link

https://puj.journals.ekb.eg/

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Article

Created At

22 Jan 2023