The identification of skeletal remains is of fundamental value in medico-legal fields. The skeletal components most often investigated for gender determination are the pelvis and skull, with the mandible especially in cases of destroyed bodies. The purpose of this study was to define the validity of mandibular measures taken through cone beam computerized tomography in sex determination and to establish a formula for such differentiation. The sample consisted of 100 cone beam computerized tomography (CBCT). The CBCT images were analyzed for five measurements; the distance from the inferior border of the mandibular body to the highest point of the alveolar crest ( IBM-HAC), the distance between the inferior margins of the mental foramen to the inferior border of mandibular body (IMMF-IBM),the distance between the superior margins of the mental foramen to the highest point of the alveolar crest (SMMF-HAC),the distance between the superior margins of the mental foramen to the inferior border of the mandible (SMMF-IBM) ,and volume of mental foramen. (VMF). Data analysis was achieved using SPSS version 22. Forward stepwise binary logistic regression analysis was accomplished to predict the probability of identifying male based on one or more independent variables. The logistic regression for the different varies revealed only the distance between the superior margins of the mental foramen to the inferior border of the mandible (SMMF-IBM), and volume of mental foramen. (VMF) as the significant contributors to the regression model. The logistic regression model was statistically significant and able to 75% of the difference in sex and accurately categorized all cases. Based on the logistic regression model, an equation for prediction of sex was derived. In conclusion, the current study demonstrates the probability of sex determination employing mandibular measurements taken thought CBCT that is proved as a superior tool if compared with the other radiological techniques.