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279331

Nanoparticle zinc oxide obviates oxidative stress of liver cells in induced-diabetes mellitus model

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Last updated: 03 Jan 2025

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Abstract

Background: Because of vital features including biocompatibility, high surface reactivity, and oxidation resistance, emerging nanomedicine is well-known for its potential therapeutic prospects. The goal of this study is to see if nanoparticle zinc oxide (ZnONPs) may reduce hepatic problems and oxidative stress in rats with diabetes mellitus induced by streptozotocin (STZ). Materials and methods: This study included 39 rats separated into three groups, each consisting of 13 rats; control group, streptozotocin group, and streptozotocin + ZnONPs group. Malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH), and reactive oxygen species (ROS) were measured as biochemical-specific oxidative stress measures. Fasting blood sugar (FBS), haemoglobin A1c (HbA1C), and tumour necrosis factor (TNF-β) were also measured, as well as total cholesterol and triglycerides. The percentage of P53 in the liver was determined. Inflammatory cell infiltration and fibrosis in tissues were also seen by histological investigation. Results: FBS, HbA1C, liver function tests, MDA, NO, ROS, P53, and TNF-β serum levels were increased in STZ-treated rats. Treatment with ZnONPs (5 mg/kg) in the STZ+ ZnONPs group significantly improved, FBS, HbA1C, MDA, NO, GSH, ROS, liver function, fasting blood sugar, HbA1C, and tumour necrosis factor. In addition, ZnONPs treatment banned inflammatory cell infiltration and P53 in STZ-administered rats. Conclusion: Our study provides evidence that ZnONPs may aid in controlling hepatic oxidative stress in STZ-induced diabetes mellitus in rats.

DOI

10.21608/mjvh.2022.279331

Keywords

Nano zinc oxide, oxidative stress, streptozotocin, hepatic disorders, and diabetes mellitus

Authors

First Name

Alaa

Last Name

Elmetwalli

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Affiliation

Department of Clinical Trial Research Unit and Drug Discovery, Egyptian Liver Research Institute and Hospital (ELRIAH), Mansoura, Egypt.

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dr.prof2011@gmail.com

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-

Orcid

0000-0001-5371-4297

First Name

Jihan

Last Name

Hassan

MiddleName

-

Affiliation

Colleague Medical Research Institute, Department of Applied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.

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-

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-

Orcid

-

First Name

Heba

Last Name

Alaa

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-

Affiliation

Department of Botany and Microbiology, Faculty of Science, Benha University, Benha 33516, Egypt.

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-

City

-

Orcid

-

First Name

Mervat

Last Name

Hassan

MiddleName

G.

Affiliation

Department of Botany and Microbiology, Faculty of Science, Benha University, Benha 33516, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Ali

MiddleName

-

Affiliation

Biochemistry Division, Chemistry Department, Faculty of Science, Zagazig University 44519

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-

City

-

Orcid

-

First Name

M.

Last Name

Eltayeb

MiddleName

Fikry

Affiliation

Department of Botany and Microbiology, Faculty of Science, Benha University, Benha 33516, Egypt.

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-

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-

Orcid

-

First Name

Eman

Last Name

Mousa

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-

Affiliation

Faculty of Dentistry, Mansoura University, Mansoura, Egypt.

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-

Orcid

-

First Name

Mohamed

Last Name

Salah

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-

Affiliation

Tropical Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Email

msalah61082@gmail.com

City

-

Orcid

-

First Name

Mohammed

Last Name

Abdelaziz

MiddleName

-

Affiliation

Tropical Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

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-

City

-

Orcid

-

First Name

Khaled

Last Name

Taha

MiddleName

-

Affiliation

Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

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-

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-

Orcid

-

First Name

Ola

Last Name

El-Emam

MiddleName

-

Affiliation

Clinical Pathology Department, Mansoura University, Mansoura, Egypt.

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-

Orcid

-

First Name

Sama

Last Name

EL-Sakka

MiddleName

A.

Affiliation

Animal Physiology, Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt

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-

City

-

Orcid

-

First Name

Amina

Last Name

Tolba

MiddleName

M.

Affiliation

Department of Anatomy, Faculty of Medicine, for Girls, Al-Azhar University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Alaa

Last Name

Habib

MiddleName

-

Affiliation

Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

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-

City

-

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-

Volume

7.1

Article Issue

1

Related Issue

38624

Issue Date

2022-12-01

Receive Date

2022-08-01

Publish Date

2022-12-01

Page Start

8

Page End

12

Print ISSN

2314-8748

Online ISSN

2314-8756

Article File

MJVH_Volume 7.1_Issue 1_Pages 8-12.pdf

PDF . 530.1kB

Link

https://mjvh.journals.ekb.eg/article_279331.html

Detail API

https://mjvh.journals.ekb.eg/service?article_code=279331

Order

2

Type

Original article

Type Code

477

Publication Type

Journal

Publication Title

Medical Journal of Viral Hepatitis

Publication Link

https://mjvh.journals.ekb.eg/

MainTitle

Nanoparticle zinc oxide obviates oxidative stress of liver cells in induced-diabetes mellitus model

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Article

Created At

22 Jan 2023