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258088

Transient Elastography and its Correlation with Biochemical Scores in patients with Metabolic associated fatty liver disease

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Last updated: 22 Jan 2023

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Abstract

Background: Metabolic-associated fatty liver disease (MAFLD) is a recently terminology to refer to the diseases within the field of fatty liver disease. The aim of this study is to evaluate the value of transient elastography (TE) in MAFLD patients and its correlation with clinical and biochemical scores for assessment of liver fibrosis. Methods:This study was carried out on 97 patients with MAFLD. All patients had undergone pelvi–abdominal ultra-sound as a screening tool, transient elastography to determine degree of steatosis/fibrosis, laboratory work up and calculation of FIB-4, APRI, NAFLD fibrosis score (NFS). Results:Based on the results of transient elastography, the studied MAFLD patients were classified into two groups; group (1) included 62 patients without fibrosis (F0 ≤  6 KP) and group 2 included 35 patients with fibrosis (> 6 KP).  There was significant increasing as regarding FIB4, APRI, and NFS in MAFLD patients with fibrosis versus patients without fibrosis, while controlled attenuation parameter (CAP) does not show significant difference. In patients with fibrosis (group 2) there was statistically significant positive correlation of LSM with FIB4, NFS (P< 0.0001), APRI (P= 0.001), while a non-significant negative correlation of LSM with CAP was detected (P = 0.2), furthermore, there was statistically significant correlation of LSM with age,2 hours postprandial blood sugar, HbA1c, triglycerides, serum creatinine, uric acid and platelets. Conclusion:In MAFLD patients, transient elastography is a simple, non-invasive and inexpensive method that correlates with other non-invasive assessment scores of liver fibrosis.  

DOI

10.21608/mjvh.2022.258088

Keywords

Metabolic associated fatty liver disease, Transient elastography

Authors

First Name

Ahmed

Last Name

Mosaad

MiddleName

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Affiliation

Tropical Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

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Orcid

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First Name

Hatem

Last Name

Elalfy

MiddleName

-

Affiliation

Tropical Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

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City

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Orcid

-

First Name

Talaal

Last Name

Amer

MiddleName

-

Affiliation

Department of Radiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

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City

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Orcid

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First Name

Mona

Last Name

Arafa

MiddleName

-

Affiliation

Tropical Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

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-

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-

Orcid

-

Volume

6.3

Article Issue

3

Related Issue

36449

Issue Date

2022-08-01

Receive Date

2022-06-17

Publish Date

2022-08-31

Page Start

22

Page End

28

Print ISSN

2314-8748

Online ISSN

2314-8756

Link

https://mjvh.journals.ekb.eg/article_258088.html

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https://mjvh.journals.ekb.eg/service?article_code=258088

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4

Type

Original article

Type Code

477

Publication Type

Journal

Publication Title

Medical Journal of Viral Hepatitis

Publication Link

https://mjvh.journals.ekb.eg/

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Article

Created At

22 Jan 2023