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193420

Genetic Variability of NS5B Region of Hepatitis C Virus in Togo

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Last updated: 22 Jan 2023

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Abstract

Background: Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The high prevalence and spread rates of the disease require serious actions to stop these rates. Determination of HCV genotypes and subgenotypes adds significant knowledge about the epidemiology of the disease, and provides and added value in the decision-making process of what strategy to follow and what therapy response to expert. The molecular epidemiology and genetic variability of HCV variant circulating in Togo still need further analysis.  Materials and methods: The HCV molecular epidemiology in Togo was studies using direct sequencing and further phylogenetic analysis of a partial NS5B region of the HCV from 56 patients. HCV genotype and subtype were successfully determined in 41 out of 53. Results: The highest prevalent genotype was genotype 2, which was found in 30 patients (73,2%) followed by genotype 1 that was isolated from 7 patients (17,1%), genotype 4 was isolated from 3 patients (7,3%) and 1 patient (2,4%) was infected by genotype 6. Conclusion: The molecular epidemiology study revealed high prevalence of genotype 2 among Togolese patients followed by genotype 1.

DOI

10.21608/mjvh.2021.193420

Keywords

Hepatitis C virus, genotype, Togo

Authors

First Name

Folly

Last Name

Anyovi

MiddleName

-

Affiliation

Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR-SVT, Joseph KI-ZERBO University, Ouagadougou, Burkina Faso. , Pietro Annigoni Biomolecular Research Center (CERBA), 01 BP 364 Ouagadougou 01, Burkina Faso.

Email

folly.anyovi@gmail.com

City

-

Orcid

-

First Name

Alexandre

Last Name

Soulier

MiddleName

-

Affiliation

Centre National de Référence des Hépatites virales B, C et delta, Laboratoire de Virologie, hôpital Henri Mondor, Université Paris-Est, Créteil. , INSERM U955, Créteil.

Email

-

City

-

Orcid

-

First Name

Lila

Last Name

Poiteau

MiddleName

-

Affiliation

3Centre National de Référence des Hépatites virales B, C et delta, Laboratoire de Virologie, hôpital Henri Mondor, Université Paris-Est, Créteil. , INSERM U955, Créteil

Email

-

City

-

Orcid

-

First Name

Reham

Last Name

Soliman

MiddleName

-

Affiliation

Egyptian Liver Research Institute and Hospital (ELRIAH), Sherbin, El Mansoura, Egypt , Tropical Medicine Department, Faculty of Medicine, Port Said University, Egypt

Email

rehamelsayed@hotmail.com

City

-

Orcid

-

First Name

Simplice

Last Name

Karou

MiddleName

D.

Affiliation

5Ecole Supérieure des Techniques Biologiques et Alimentaires (ESTBA), Université de Lomé.

Email

-

City

-

Orcid

-

First Name

Jacques

Last Name

Simpore

MiddleName

-

Affiliation

Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR-SVT, Joseph KI-ZERBO University, Ouagadougou, Burkina Faso. , Pietro Annigoni Biomolecular Research Center (CERBA), 01 BP 364 Ouagadougou 01, Burkina Faso.

Email

-

City

-

Orcid

-

First Name

Stephane

Last Name

Chevaliez

MiddleName

-

Affiliation

Centre National de Référence des Hépatites virales B, C et delta, Laboratoire de Virologie, hôpital Henri Mondor, Université Paris-Est, Créteil. , INSERM U955, Créteil.

Email

-

City

-

Orcid

-

First Name

Gamal

Last Name

Shiha

MiddleName

-

Affiliation

Internal Medicine dept., Mansoura Univ., Egypt , Egyptian Liver Research Institute and Hospital (ELRIH), Sherbin, El-Mansoura, Egypt.

Email

g_shiha@hotmail.com

City

-

Orcid

-

Volume

5.3

Article Issue

3

Related Issue

27528

Issue Date

2021-09-01

Receive Date

2021-05-01

Publish Date

2021-09-01

Page Start

8

Page End

13

Print ISSN

2314-8748

Online ISSN

2314-8756

Article File

MJVH_Volume 5.3_Issue 3_Pages 8-13.pdf

PDF . 331.3kB

Link

https://mjvh.journals.ekb.eg/article_193420.html

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https://mjvh.journals.ekb.eg/service?article_code=193420

Order

2

Type

Original article

Type Code

477

Publication Type

Journal

Publication Title

Medical Journal of Viral Hepatitis

Publication Link

https://mjvh.journals.ekb.eg/

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Article

Created At

22 Jan 2023