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193408

Culture negative neutrocytic ascites versus culture positive spontaneous bacterial peritonitis; Is there a Difference; A Multi-Centric Study

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Last updated: 22 Jan 2023

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Abstract

Background: There are two variants of spontaneous bacterial peritonitis (SBP) include, culture negative neutrocytic ascites (CNNA) and culture positive SBP. Some suggested that, the clinical presentation of two variants is nearly similar, however, other reported that, patients with culture positive have a more severe course and higher mortality than CNNA. The aim of this study is to determine the clinical characteristics and predictors of CNNA in comparison to culture positive SBP.
Materials and methods: This study included 300 consecutive patients with HCV related cirrhotic ascites. All patients underwent abdominal paracentesis and the ascitic fluid was processed for cell count and culture. Clinical and laboratory parameters of these patients were recorded at index admission.. Results: Out of 300 patients included in the study, 150 patients had SBP. Among the 150 patients with SBP, 100 patients were culture positive SBP (culture positive SBP with ascitic fluid PMNL ≥250 cells/m3) and 50 patients were CNNA (culture negative SBP with ascitic fluid PMNL ≥250 cells/m3). Compared to patients with culture positive SBP, patients with CNNA showed, a significant decrease as regards, fever, prevalence of DM, hepatic encephalopathy, platelets, blood PMNL and ascetic PMNL. Logistic regression analysis demonstrated that, decreased platelets count, blood PMNL and ascetic PMNL were independent predictor factors for CNNA.
Conclusion: Patients with CNNA have a lower incidence of fever, prevalence of diabetes mellitus, hepatic encephalopathy, blood PMNL and ascetic PMNL versus culture positive SBP. Independent predictors of culture negative SBP are decreased platelets, blood PMNL and ascetic PMNL.

DOI

10.21608/mjvh.2021.193408

Keywords

Ascitic fluid infections, Spontaneous Bacterial Peritonitis, culture negative neutrocytic ascites, culture positive spontaneous bacterial

Authors

First Name

Ahmed

Last Name

Yassen

MiddleName

-

Affiliation

Tropical Medicine Department, Mansoura University, Egypt

Email

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Orcid

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First Name

Nasser

Last Name

Mousa

MiddleName

-

Affiliation

9 Mohamed Arafa street from Ahmed Maher street, Masoura, Dakahlia Governorate, Egypt

Email

mousa_medic@yahoo.com

City

Mansoura

Orcid

-

First Name

Ahmed

Last Name

Abdel-Razik

MiddleName

-

Affiliation

Tropical Medicine Department, Mansoura University, Egypt.

Email

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City

-

Orcid

-

First Name

Rasha

Last Name

Mahmoud

MiddleName

-

Affiliation

Internal Medicine Department, Mansoura University, Egypt.

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-

City

-

Orcid

-

First Name

Alaa

Last Name

Habib

MiddleName

-

Affiliation

Internal Medicine Department, Mansoura University, Egypt.

Email

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City

-

Orcid

-

First Name

Eman

Last Name

Mousa

MiddleName

-

Affiliation

Faculty of Dentistry, Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Niveen

Last Name

El-Wakeel

MiddleName

-

Affiliation

Medical Microbiology and Immunology, Mansoura University, Egypt.

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City

-

Orcid

-

First Name

Aya

Last Name

Fathy

MiddleName

-

Affiliation

Public health and community medicine, Mansoura University, Egypt

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City

-

Orcid

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First Name

Sally

Last Name

Mostafa

MiddleName

Abdallah

Affiliation

Medical Biochemistry and Molecular Biology Department, Mansoura University, Egypt.

Email

-

City

-

Orcid

-

First Name

Narmin

Last Name

Saied

MiddleName

-

Affiliation

Clinical Pathology Department, Mansoura University, Egypt.

Email

-

City

-

Orcid

-

First Name

Muhammad

Last Name

Diasty

MiddleName

-

Affiliation

Tropical Medicine Department, Mansoura University, Egypt.

Email

-

City

-

Orcid

-

First Name

Aya

Last Name

Mousa

MiddleName

-

Affiliation

Faculty of physical therapy, Galala university, Egypt.

Email

-

City

-

Orcid

-

First Name

Essam

Last Name

Elmahdi

MiddleName

-

Affiliation

Internal Medicine Department, Mansoura University, Egypt.

Email

-

City

-

Orcid

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Volume

5.3

Article Issue

3

Related Issue

27528

Issue Date

2021-09-01

Receive Date

2021-05-01

Publish Date

2021-09-01

Page Start

1

Page End

7

Print ISSN

2314-8748

Online ISSN

2314-8756

Article File

MJVH_Volume 5.3_Issue 3_Pages 1-7.pdf

PDF . 351.3kB

Link

https://mjvh.journals.ekb.eg/article_193408.html

Detail API

https://mjvh.journals.ekb.eg/service?article_code=193408

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Original article

Type Code

477

Publication Type

Journal

Publication Title

Medical Journal of Viral Hepatitis

Publication Link

https://mjvh.journals.ekb.eg/

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Article

Created At

22 Jan 2023