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4571

Comparison between Transient Elastography (FibroScan) and Liver Biopsy for the Diagnosis of Hepatic Fibrosis in Chronic Hepatitis C Patients

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Last updated: 22 Jan 2023

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Abstract

Transient elastography (TE) is gaining popularity as a non-invasive method for predicting liver fibrosis. The practical utility of the method is based on establishing cutoff values for each stage of fibrosis. A diagnosis of stage is based on measurements of liver stiffness that vary in different studies. The present study aimed to establish cutoff values for each stage of fibrosis to assess the performance of TE in fibrosis staging in Egyptian chronic HCV patients. This cross-sectional study was conducted at Specialized Medical Hospital and the Egyptian Liver Foundation, Mansoura, Egypt. The inclusion
criteria were: age older than 18 years and chronic infection by hepatitis C. The exclusion criteria were the presence of ascites, pacemaker or pregnancy. Three hundred and fifty six consecutive patients with chronic hepatitis C participated in the study. Liver fibrosis was staged according to the METAVIR system. The AUROCs for F2 or greater, F3 or greater and cirrhosis (F4) were 0.91 (95% CI 0.87 to 0.94), 0.95 (95% CI 0.91 to 0.99) and 0.97 (95% CI 0.96 to 0.99), respectively. ROC curve analysis identified optimal cutoff value of liver stiffness measurements as high as 9.8 kPa for F ≥ 2, 10.4 kPa for F ≥ 3, and 17.2 kPa for F = 4. The overall relation between fibrosis stages when comparing both FibroScan and biopsy was significant agreement between both (the kappa measure was 0.430 and p<0.001). TE is a good non-invasive
tool for diagnosis and monitoring of liver fibrosis among patients with Chronic HCV infection.

DOI

10.21608/mjvh.2016.4571

Keywords

Transient elastography, FibroScan, Liver Biopsy, Chronic hepatitis C

Authors

First Name

Shiha

Last Name

G.

MiddleName

-

Affiliation

Egyptian Liver Research Institute and Hospital (ELRIH), Sherbin, El-Mansoura, Egypt, Hepatology & Gastroenterology unit, Internal Medicine Department, Faculty of Medicine,El-Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

El-Etreby

Last Name

S.

MiddleName

-

Affiliation

Hepatology & Gastroenterology unit, Internal Medicine Department, Faculty of Medicine,El-Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Bahgat

Last Name

M.

MiddleName

-

Affiliation

Hepatology & Gastroenterology unit, Internal Medicine Department, Faculty of Medicine,El-Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Hamed

Last Name

M.

MiddleName

-

Affiliation

Hepatology & Gastroenterology unit, Internal Medicine Department, Faculty of Medicine,El-Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

El Sherbini

Last Name

M

MiddleName

-

Affiliation

Hepatology & Gastroenterology unit, Internal Medicine Department, Faculty of Medicine,El-Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Ghoneem

Last Name

EA.

MiddleName

-

Affiliation

Hepatology & Gastroenterology unit, Internal Medicine Department, Faculty of Medicine, El-Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Zalata

Last Name

K.

MiddleName

-

Affiliation

Pathology Department, Faculty of Medicine, El-Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Soliman

Last Name

R.

MiddleName

-

Affiliation

Egyptian Liver Research Institute and Hospital (ELRIH), Sherbin, El-Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

El-Basiouny

Last Name

M.

MiddleName

-

Affiliation

Egyptian Liver Research Institute and Hospital (ELRIH), Sherbin, El-Mansoura, Egypt, Hepatology & Gastroenterology unit, Internal Medicine Department, Faculty of Medicine,El-Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Mikhail

Last Name

NNH.

MiddleName

-

Affiliation

Egyptian Liver Research Institute and Hospital (ELRIH), Sherbin, El-Mansoura, Egypt,Department of Biostatistics, South Egypt Cancer Institute, Assiut University, Egypt

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-

City

-

Orcid

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Volume

2.1

Article Issue

1

Related Issue

753

Issue Date

2016-11-01

Receive Date

2016-07-17

Publish Date

2016-11-01

Page Start

1

Page End

9

Print ISSN

2314-8748

Online ISSN

2314-8756

Article File

MJVH_Volume 2.1_Issue 1_Pages 1-9.pdf

PDF . 196.2kB

Link

https://mjvh.journals.ekb.eg/article_4571.html

Detail API

https://mjvh.journals.ekb.eg/service?article_code=4571

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3

Type

Original article

Type Code

477

Publication Type

Journal

Publication Title

Medical Journal of Viral Hepatitis

Publication Link

https://mjvh.journals.ekb.eg/

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Details

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Article

Created At

22 Jan 2023