163780

Semen parameters in Egyptian diabetic patients and its correlation with glycosylated hemoglobin level: A case - control study

Article

Last updated: 03 Jan 2025

Subjects

-

Tags

Semen

Abstract

Background: Diabetes mellitus (DM) is a well-known metabolic disorder affecting a large population worldwide. Both types of DM could have detrimental effects on semen parameters as well as the hormonal profile of the affected males.
Objective: On designing the current study, we sought to evaluate the effect of long-term control of DM by measuring glycosylated hemoglobin (HbA1c) level and detect its possible correlation with semen parameters and hormonal profile of male patients with DM.
Patients and Methods: A prospective case–control study was conducted on 60 males with DM and 40 matched controls. All participants were subjected to conventional semen analysis and measurement of free and total testosterone, follicle-stimulating hormone, luteinizing hormone, and prolactin levels by enzyme-linked immunosorbent assay technique. Measurement of HbA1c level was made for all participants.
Results: A significant negative correlation was found between HbA1c and free testosterone levels, whereas a significant positive correlation between HbA1c and prolactin levels in patients with DM. No significant correlation was reported between HbA1c and semen parameters in patients with DM.
Conclusion: Patients with DM have significantly lower semen parameters and reproductive hormone levels than matched healthy controls which might impair their fecundity and reproductive capacity. We do recommend that all males with abnormal semen analysis should undergo screening for DM.

DOI

10.21608/ha.2020.29700.1061

Keywords

Diabetes mellitus, Glycosylated Hemoglobin, semen parameters

Authors

First Name

Emad Eldien

Last Name

Kamal

MiddleName

-

Affiliation

Dermatology, Venereology and Andrology Department, Faculty of Medicine, Assuit University, Assuit, Egypt

Email

emad@fertility-eg.com

City

Assiut

Orcid

-

First Name

AYA

Last Name

BADRAN

MiddleName

-

Affiliation

Dermatology, Venereology and Andrology Department, Faculty of Medicine, Assuit University, Assuit, Egypt

Email

aya_badran@yahoo.com

City

ASSUIT

Orcid

0000-0001-5331-5792

First Name

Walaa

Last Name

Khalifa

MiddleName

-

Affiliation

Internal Medicine Department, Faculty of Medicine, Assuit University, Assuit, Egypt.

Email

walaaanwar@aun.edu.eg

City

-

Orcid

-

First Name

Angham

Last Name

Mahgoob

MiddleName

-

Affiliation

Dermatology, Venereology and Andrology Department, Faculty of Medicine, Assuit University, Assuit, Egypt.

Email

angham88@yahoo.com

City

-

Orcid

-

First Name

Mohammed

Last Name

Abukrisha

MiddleName

-

Affiliation

Department of clinical pathology

Email

mohammedabukrisha@aun.edu.eg

City

Assiut

Orcid

-

First Name

Reham

Last Name

Abdel Gaber

MiddleName

M

Affiliation

Dermatology, Venereology and Andrology Department, Faculty of Medicine, Assuit University, Assuit, Egypt.

Email

rehamaher@aun.edu.eg

City

-

Orcid

-

Volume

11

Article Issue

11

Related Issue

23903

Issue Date

2021-04-01

Receive Date

2020-05-08

Publish Date

2021-04-01

Page Start

1

Page End

6

Print ISSN

2090-6048

Online ISSN

2090-6056

Link

https://ha.journals.ekb.eg/article_163780.html

Detail API

https://ha.journals.ekb.eg/service?article_code=163780

Order

1

Type

Original Article

Type Code

367

Publication Type

Journal

Publication Title

Human Andrology

Publication Link

https://ha.journals.ekb.eg/

MainTitle

Semen parameters in Egyptian diabetic patients and its correlation with glycosylated hemoglobin level: A case - control study

Details

Type

Article

Created At

22 Jan 2023