Background: Recurrent pregnancies loss (RPL) is physically andemotionally devasting situation for the parents, along with
difficult situationfor obstetrician to handle.  Aim of the Work: The present study aimed at investigation of the significanceof various etiology in relation to pregnancy outcome in cases ofunexplained recurrent pregnancy loss.
Materials And Methods: It is a retrospective analysis of 100 patientswho presented to El-Shatby maternity university
hospital, betweenMay 2017 to October 2018, with history of two or more unexplained earlytrimester abortions fullfiling
the common investigations done for thesecases. all the patients during mid-luteal phase, examined by transvaginal3D pulse Doppler ultrasound to detect endometrial perfusion with measuringin the sera 25-hydroxy vitamin D3 and B2 glycoprotein 1 antibodieswhich is a marker of antiphospholipid syndrome. evaluation of uterineartery blood flow and subendometrial blood flow, detection uterine arterypulsatility index (UAPI) and subendometrial blood flow presented by the indiciesvascularisation index (VI), flow index (FI) and vascular flow index(VFI).
Results and Conclusion: All of the studied parameters namely; doppler indices, vitamin D level and B2glycoprotien were
significantly related to the incidence of the pregnancy loss and should be tested in those particular category of women who are at risk of recurrent pregnancy loss.