Background: Oxytocin is the agent of choice in the prevention of postpartum uterine atony and bleeding. This study aims at assessment of the efficacy of oxytocin infusion on reducing blood loss during abdominal myomectomy.Materials and Methods: The current study was a randomized double-blind controlled trial conducted in a tertiary University Hospital. The study participants were randomized to one of two groups; Group 1 included 30 women                received 30 IU of (Oxytocin) in 500 ml normal saline administered during abdominal myomectomy and Group 2                                    included 30 women received only saline infusion administered during the surgery. The primary outcome is the difference in mean blood loss in both groups.Results: The estimated blood loss was significantly lower among oxytocin group in comparison to the control group as well as significantly higher Postoperative hemoglobin and hematocrit with significantly lower Hematocrit                                           reduction (p<0.001). It showed also significant less blood transfusion in the post operative period among oxytocin                  group (p=0.044) as well as significantly shorter operative duration, ambulation time and duration of hospital stay.Conclusion:Oxytocin infusion could reduce the blood loss during abdominal myomectomy in the lowest effective and safest dose.