Objective: The aim of the study was to evaluate the effect of prolonged use of hormonal contraception on ovarian reserve.
Patients and Methods: This study was performed on fifty (50) patients who were divided into two groups. First group (study group): included 25 participants after prolonged use of hormonal contraception (more than 3 years). Volunteers who had been using the COCP or injectable progesterone or subdermal progesterone implant for more than last 3 years. Second group: included 25 participants from non-users of hormonal contraception as controls.
Results: We found that there is no significant difference between AMH and AFC between combined methods and progesterone only methods in the study group showing similar results between different types of contraception. Also, the results showed that AMH and AFC are negatively correlated with age and BMI while there is positive correlation between AMH and AFC. P value (<0.001) in both cases and controls groups.
Conclusion: Actually, in this study, it was found that AMH and AFC are still considered as the best markers of ovarian reserve even in individuals who are already on hormonal contraceptive use. In addition, AMH and AFC affected negatively by age and obesity.