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28769

Letrozole Ovarian Stimulation improves Outcome of Endometrial Scratching prior to Intrauterine Insemination Procedure

Article

Last updated: 03 Jan 2025

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Tags

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Abstract

(OS) followed by endometrial scratching (ES) versus after each intervention separately.
Patients and Methods: This study included 90 women with primary infertility for >2years secondary to male factor and had previous failed IUI or expectant trials. All women underwent clinical examination and transvaginal ultrasonographic (TUV) examination and hormonal profile. Enrolled couples were randomly divided into three groups: Group L received oral letrozole 5 mg from day 3 to 7 of the menstrual cycle, Group S included females subjected to ES injury and Group LS included females received LET OS followed by ES injury. For all groups, ovulation was monitored and assured using TVU for evident ovulation with a dominant follicle size >18 mm. IUI was repeated for three cycles and clinical pregnancy rate (CPR) and abortion and multiple pregnancy rates were recorded.
Results: The studied women gave 287 follicles of >18 mm with a mean number of follicles of 3.18/female and 1.35/cycle. Mean endometrial thickness was significantly lower, while E2 serum levels were significantly higher in women of group S compared to women of other groups. Total CPR was 41.1%/woman and 17.4%/cycle with significant difference in favor of group LS. Two patients of groups L and LE had multiple pregnancy and 5 women had abortion for a rate of 5.6%/woman and 2.3%/cycle.
Conclusion: Letrozole OS did better to prepare for IUI in infertile couple secondary to male subfertility. ES prior to IUI improved the chances of clinical pregnancy and could be an alternative to OS whenever OS had failed or contraindicated. ES after letrozole OS followed by IUI augments the CPR up to 53.3%/patient.

DOI

10.21608/EBWHJ.2019.28636

Keywords

Clinical pregnancy rate, Endometrial scratch, Intrauterine insemination, Letrozole ovarian stimulation, Male factor infertility

Authors

First Name

Ahmed

Last Name

Hagras

MiddleName

M

Affiliation

Departments of Obstetrics and Gynecology, Faculty of Medicine, Tanta Universities

Email

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City

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Orcid

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First Name

Ehab

Last Name

Barakat

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Banha University, Egypt

Email

drehabmarzouk@yahoo.com

City

-

Orcid

-

Volume

9

Article Issue

1

Related Issue

5102

Issue Date

2019-02-01

Receive Date

2019-03-17

Publish Date

2019-02-01

Page Start

337

Page End

343

Print ISSN

2090-7265

Online ISSN

2090-7257

Link

https://ebwhj.journals.ekb.eg/article_28769.html

Detail API

https://ebwhj.journals.ekb.eg/service?article_code=28769

Order

3

Type

Original Article

Type Code

366

Publication Type

Journal

Publication Title

Evidence Based Women's Health Journal

Publication Link

https://ebwhj.journals.ekb.eg/

MainTitle

Letrozole Ovarian Stimulation improves Outcome of Endometrial Scratching prior to Intrauterine Insemination Procedure

Details

Type

Article

Created At

22 Jan 2023