Beta
6215

Serum progesterone concentrations before and after human chorionic gonadotropin triggering and invitro fertilization : Intracytoplasmic sperm injection cycle outcome in long gonadotrophin releasing hormone agonist protocol

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

-

Abstract

Objective: To assess the impact of serum progesterone concentrations before and after HCG triggering on IVF/ICSIcycle outcomes in long GnRHa protocol.
Patients and Methods: This is a single-center prospective observational cohort study, in which 102 IVF/ICSI patients with normal cycle day 2 basal hormones were recruited and underwent ovarian stimulation using the long GnRHa protocol. Serum progesterone on the day of HCG trigger; one day after, progesterone/estradiol was assessed and correlated with pregnancy rates, the total dose of used gonadotropins, serum estradiol level on day of trigger, the number of collected oocytes, the number of metaphase II oocytes and the quality of transferred embryos.
Results: 96 women were included in the analysis. In our study, the receiver-operating characteristic (ROC) analysis was used to gain more diagnostic accuracy. Our data according to ROC analysis showed that the P levels on the day of hCG trigger, and its levels one day after and P/E2 on the day of hCG trigger had no role in prediction of clinical pregnancy rates. There was significant correlation between the serum progesterone levels before and after HCG triggering with the total dose of gonadotropins used. They also correlated strongly with serum estradiol level on day of trigger, the number of collected oocytes and the number of metaphase II oocytes.
Conclusion: Peri-ovulatory serum progesterone concentrations cannot predict pregnancy rates in IVF/ICSI cycles using long GnRHa protocol.

DOI

10.21608/ebwhj.2018.6215

Keywords

Gonadotrophin releasing hormone agonist, IVF/ICSI, pregnancy rate, periovulatory, serum progesterone concentrations

Authors

First Name

Mona

Last Name

Shaban

MiddleName

M.

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Email

drmonashaban@gmail.com

City

-

Orcid

-

First Name

Yasmin

Last Name

Bassiouny

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

Alahwany

MiddleName

Amr

Affiliation

Department of Andrology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Email

-

City

-

Orcid

-

Volume

8

Article Issue

1

Related Issue

967

Issue Date

2018-02-01

Receive Date

2017-12-02

Publish Date

2018-02-01

Page Start

138

Page End

143

Print ISSN

2090-7265

Online ISSN

2090-7257

Link

https://ebwhj.journals.ekb.eg/article_6215.html

Detail API

https://ebwhj.journals.ekb.eg/service?article_code=6215

Order

4

Type

Original Article

Type Code

366

Publication Type

Journal

Publication Title

Evidence Based Women's Health Journal

Publication Link

https://ebwhj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023