Objectives: To investigate the effect of body mass index (BMI) on outcome of IVF/ICSI in Egyptian women with
PCOS.Study design: Retrospective cohort study.
Patients And Methods: The study included including 253 women with PCOS (study group) and 253 women with tubal
or unexplained infertility (control group) that underwent IVF/ICSI treatment at Minia IVF Center in Egypt in the period
between January 2013 and December 2015.
Results: The number of retrieved oocytes and the total number of embryos were significantly higher in women with
PCOS compared to the control group (P=0.003 and 0.002 respectively). There was no significant difference between
the two groups as regards the clinical pregnancy rate (CPR), live birth rate and miscarriage rate. More cases of ovarian
hyperstimulation syndrome (OHSS) were diagnosed in the PCOS group (24 vs. 5. P=0.3). When stratified for BMI,
lean PCOS women (BMI< 25) had higher CPR (35% vs. 28.2, P=0.01), live birth rate (32% vs. 26.1%, P =0.01). There
were more cases of OHSS in lean as compared with overweight and obese PCOS women (19% vs. 3.3%, P = 0.05).
Conclusion: Lean PCOS women achieved higher CPR and live birth rate in IVF/ICSI compared to overweight and
obese PCOS women in Egyptian population.