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267997

Blood Urea Nitrogen to Albumin Ratio is a Predictor of Mortality among Hospitalized Geriatric Patients with COVID-19.

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Last updated: 03 Jan 2025

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Abstract

Aim: This study aims to determine predictors of mortality among hospitalized geriatric patients with COVID-19 with a particular concern about the predictive value of blood urea nitrogen to albumin ratio (BAR). Methods: A retrospective cohort study included 114 geriatric patients (aged ≥ 60 years) admitted to a geriatric hospital for isolation. A review of the medical files of participants was conducted to extract data regarding age, sex, comorbidities, clinical manifestations of COVID-19 and laboratory data including haematology, biochemistry and inflammatory markers on admission. BAR and Charlson comorbidity index (CCI) was calculated. The primary outcome was in-hospital mortality. Appropriate statistical analyses were operated. RESULTS: 59 (51.8%) patients died at the hospital. Comorbidities associated with mortality included diabetes mellitus, old stroke, hypertension, and cardiac disease besides higher CCI. Reporting of fever, fatigue, sore throat and delirium /altered mental status were also associated with mortality. Significant biomarkers included lower haemoglobin and serum albumin, higher total leukocyte count, serum creatinine, blood urea nitrogen, lactate dehydrogenase, D-dimer, c-reactive protein (CRP) and BAR. BAR at a cutoff of 12.92 mg/gm had the best predictive performance for mortality. Serum BAR > 12.92 mg/gm, albumin < 3.05 g/dl and CRP > 108 mg/l were independent predictors of in-hospital mortality CONCLUSION: Serum BAR > 12.92 mg/gm, albumin < 3.05 g/dl and CRP > 108 mg/l are independent predictors of mortality among hospitalized geriatric patients with COVID-19. BAR is a convenient biomarker and has the best predictive performance to early pick up COVID-19 geriatric patients at high risk of mortality. 

DOI

10.21608/ejgg.2022.267997

Keywords

Keywords: Blood Urea Nitrogen to Albumin ratio, Older adults, SARS-CoV-2

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Khalid E. Elsorady et al.,

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Volume

9

Article Issue

2

Related Issue

37462

Issue Date

2022-10-01

Receive Date

2022-11-01

Publish Date

2022-10-01

Page Start

68

Page End

85

Print ISSN

2356-8712

Online ISSN

2536-9792

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https://ejgg.journals.ekb.eg/article_267997.html

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https://ejgg.journals.ekb.eg/service?article_code=267997

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6

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Original Article

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365

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Journal

Publication Title

The Egyptian Journal of Geriatrics and Gerontology

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https://ejgg.journals.ekb.eg/

MainTitle

Blood Urea Nitrogen to Albumin Ratio is a Predictor of Mortality among Hospitalized Geriatric Patients with COVID-19.

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Article

Created At

22 Jan 2023