The aim of the study is to assess the effectiveness of 14-days course of Clarithromycin-based triple therapy as first line therapy for H. pylori infection in Egyptian elderly patients with normal liver and kidney functions. Methods: The study was
experimental study carried out on 34 elderly patients having H. pylori gastritis with normal liver and kidney functions. We tested for H. pylori stool antigen using a quantitative monoclonal enzyme-linked immunosorbent assay (ELISA) assay before and 4 weeks after the treatment to confirm eradication. Patients received Clarithromycin-based triple therapy
(Clarithromycin 500mg twice daily, Amoxicillin 1000mg twice daily, and Omeprazole 40mg twice daily) for H. pylori eradication for 14 days. Results: The cure rate of Clarithromycinbased triple therapy was 88.2% (30/34) and only 11.8% (4/34) was having persistent infection. None of the patients discontinued the drugs indicating good tolerability
.Conclusion: The use of 14-days course of Clarithromycin-based triple therapy as first line therapy for H. pylori infection is highly effective and tolerable in Egyptian elderly patients with normal liver and kidney functions.