A field trail was conducted to evaluate the efficacy of capsules suspension formulation (CS) by nanotechnology and conventional acaricides against the cattle ticks (Hyalomma marginatum) and its effects on the body weight and blood parameters of Aberdeen angus cattle. Acaricides residues were determined in an animal's blood and milk. Thirty infested cattle were randomly divided into five groups, each one contains (3 bulls and 3 cows) based on the mean tick count. Results showed that, permethrin 25 % CS and lambada-cyhalothrin 10 % CS were significantly the most effective against ticks (2.7 and 3.8 ticks/animal, respectively) compared to fipronil 20 % SC and Acetamiprid 20 % SL (8.3 and 6.3 ticks/animal, respectively) after 70 days of treatment. Permethrin 25 % CS achieved 100 % control against highly ticks' infestation after 3 days of treatment and maintained for 56 days without its residues in blood and milk samples. Conversely, fipronil residue was detected in the cow's blood and milk (1.3 and 2.7 µg/l, respectively) however, it's non detected in bull's blood after 1 week of treatment. They gradually decreased to below detection limits after 3 and 6 weeks respectively. The animal body weight was significantly increased, additionally: the liver and kidney function were decreased to normal level in all treated animals. Finally, permethrin and lambda-cyhalothrin that formulated CS can be used as efficient acaricides and a safe alternative in tick control strategy in tropical areas.