The aim of this study was to investigate the knowledge of rural women by the agricultural extension recommendations for the prevention of dairy cattle in some villages of Kafr El-Sheikh Governorate from some infectious diseases i.e., foot and mouth disease, lumpy skin disease, mastitis, and contagious abortion (brucellosis). Three villages i.e., Al Abasia (99 respondents), Kafr Magar (65 respondents), and Kom Al Hajana (50 respondents) from Kafr El-Sheikh governorate were selected based on the number of dairy cattle breeders to carry out the study. The personal questionnaire sheets were used to collect the field data. Different statistical methods were used to present the significantly differences between the mean scores of the respondents. Our results conclude that about 51 % of the total respondents have been characterized by a low level of total knowledge by the technical recommendation for the prevention of the dairy cattle from the foot and mouth disease. About 56 % of the total respondents have been characterized by a medium level of total knowledge by the technical recommendation for the prevention of the dairy cattle from the mastitis disease. About 44 % of the total respondents have been characterized by a medium level of total knowledge by the technical recommendation for the prevention of the dairy cattle from the lumpy skin disease. About 54 % of the total respondents have been characterized by a medium level of total knowledge by the technical recommendation for the prevention of the dairy cattle from the contagious abortion (brucellosis) disease.