The present investigation was carried out in the Experimental Farm of Faculty of Agriculture, Kafr El-Sheikh University during the two successive winter growing seasons of 2012/2013 and 2013/2014 in the same location to study the long term effect using one variety of wheat (Triticum aestivum L.), cv. Masr 1.The experiment was conducted in split-split plot design, with four replicates. The main plots were randomly assigned to nitrogen levels (0, 40 and 80 kg N/fed), the sub plots were represented by the two chelated forms of humic and EDTA as foliar application and the sub-sub plots were represented by four micronutrients spraying of Fe, Cu, Mn and Zn, each one in two concentrations.The objectives of the present study were to investigate the effect of different levels of N and foliar application of some chelated micronutrients on: (1) grain yield and yield component of wheat plant (2) uptake of N, P and K by wheat under different treatment of N rates and micronutrients and (3) some soil available macronutrients.The results showed that, the best treatments were N₈₀, Zn₂ and Mn₂ which gave the highest production for wheat grain and straw yield which indicate the importance of balance fertilization for wheat crop. These results also indicated that, improving soil fertility and replenishment nutrients depletion under the conditions of the present study could be achieved using previous treatments.