Pots experiment was carried out at Farm of Fac. Agric. Kafrelsheikh Univ. during 2013 and 2014 seasons to study the effect of soil type (clayey and clay+ sand (2:1v/v), some fertilization treatments (T1- control (NPK full dose ), T2- 75%NPK dose +5%FYM(from soil dry weight in pot), T3- 50%NPK dose +10%FYM, T4- 25%NPK dose + 5%FYM+2g/l active dry yeast (ADY) +200ppm ascorbic acid (AA), T5- 5%FYM+ 2g/l ADY+300ppm salicylic acid (SA),T6- 5%FYM+ 2g/l ADY+300ppm AA, T7- 2g/l ADY+300ppm of each SA or AA, T8- 10%FYM+2g/l ADY, T9- 10%FYM+200ppm of each SA or AA and T10- 10%FYM+1g/l ADY+200ppm of each SA or AA) and their interaction on the vegetative growth and chemical composition of   Adhatoda vasica..The obtained data can be summarized as follows: Effect of soil type 1- The planting in clayey soil resulted in higher values of plant height, number of shoots/plant, main stem diameter, plant leaf area and fresh and dry weights of aerial parts and roots/ plant in the two seasons, except for the pant height in the first season, and the differences between clayey and clay +sand (2:1)did not reach the significant level in case of shoot number, main steam diameter and plant leaf area in the first season also , in case of plant height in the second season. 2- The planting in clay +sand (2:1) gave higher significant values of leaf green color degree in the first season and total carbohydrates in the both seasons .While the plants cultured in clayey soil had higher values of N,P, and K% in the two seasons and the difference between the two used soils did not reach the significant level in case of N and P% in the second season only. For the effect of fertilization treatments: 1-Higher significant values of plant height resulted from T8 in the first season and T9 in the second one, shoots number/plant were recorded for T2 in the first season and T1,T2,T3and T9in the second season, main stem diameter resulted from T4 in the first season and T3in the second one, higher plant leaf area was recorded for T3 in the first season and T2 and T3 in the second one and the fresh and dry weights of aerial parts and roots resulted from applying T3in the two seasons. 2- The fertilization with T1in the first season and T2 in the second one resulted in higher values of leaf green color degree and applying T3 caused significant increases in total carbohydrates, N, P and K% in the both seasons. Concerning interaction between soil type and fertilization treatments, data showed that the planting in either clayey soil or clay +sand (2:1) soil and fertilization with treatments contain NPK at different percentages combined by FYM at different levels caused significant increases in the most growth and chemical parameters investigated in the both seasons.