In this study six mineral elements; Copper sulfate (Cu SO₄), Potassium sulfate (K2 SO₄), Micron Sulfure (S), Boric acid (H3 BO3), Copper sulfate + Micron Sulfure (Cu SO₄ + S) and Potassium sulfate + Boric acid (K2 SO₄ + H3 BO3) as well as fungicide; Montoro 30% were used as foliar spraying. These elements were evaluated against Cercospora, leaf spot disease on sugar beet under field conditions during two season; 2017/18 and 2018/19. All foliar applications were significantly reduced the disease severity % compared to untreated treatment during the two seasons. Potassium and combined application of Potassium and Boron treatments recorded the high value of sugar beet leaf dry weight over the control. Sulfure application led to an increase the fresh weight of sugar beet root, while Boron application increased the total soluble solid (TSS), sucrose % and purity %. Results obtained showed significant increasing (%) in catalase (CAT), peroxidase (POX) and polyphenolosxidase (PPO) activities in the case of mineral application and Montoro 30% fungicide compare with untreated treatment. However, the present study showed that foliar application of mineral elements tested in increased yield components of sugar beet, and thus is recommended to increase root yield and quality as well as can reduce disease severity.