Purpose: The aim of this study was to investigate the effectiveness of initial quantitative indexes of FDG PET 18F-FDG PET/CT in adult Non Hodgkin Lymphoma patients on therapy outcome. Patients and Methods: A total of 57 adult patients initially diagnosed with non-Hodgkin Lymphoma were retrospectively analyzed in this study within period of January 2018 till December 2019. Initial 18F-FDG PET/CT scan was done before chemotherapy, interim 18F-FDG PET/CT done after receiving two cycles of chemotherapy. SUV max, SUV mean SUV peak, MTV, and TLG was extracted from both initial and interim 18F-FDG PET /CT scans and recorded. Follow up period was 6 – 24 months.
Results: Regarding clinical outcome at end of chemotherapy, initial TMTV and TLG were found statistically significant (p 0.005) & (p 0.010) respectively. On multivariate analysis; ΔSUV max was found to be statistically significant (p <0.001). Regarding 2Y relapse free survival rate; initial 18F-FDG PET/CT TLG quantitative parameter was found statistically significant where 2Y-RFS rates for high- and low-TLG groups were 100% and 66.7% respectively (p 0.011).
Conclusion: ΔSUV max was found to successfully predict clinical outcome at end of chemotherapy cycles. Initial 18F-FDG PET/CT TLG quantitative parameter successfully predict 2 Y-RFS.