Aim: To evaluate the prognostic value of the initial quantitative PET/CT parameters in terms of therapy response and survival in patients with esophageal carcinoma. Material &methods: This retrospective study includes thirty-two patients (17 males and 15 females). All patients had pathologically proven esophageal cancer. These Patients underwent whole body 18F-FDG PET/CT as a baseline staging method before Neoadjuvant therapy. Initial FDG PET/CT scans were retrieved and PET volumetric images were analysed for metabolic parameters including maximum SUV (SUV max), mean SUV (SUV mean), (SUV peak), MTV and TLG. Results: 53.1% of the enrolledpatients were males and 46.9%were female with the dominating pathological subtype was Squamous cell carcinoma in 20 patients (62.5%). Quantitative analyses of the metabolic parameters of the enrolled patients revealed SUV max with average value 16.13 +/- 8.71, SUV mean with average value 9.47+/- 5.2, SUV peak with average value 13.09 +/-7.1. MTV with average value 32.5+/-21.88 and TLG with average value 332.44+/- 318 and range between (34 and 1149). Survival analysis showed that initial SUV max, SUV mean, SUV Peak of oesophageal tumour were not correlated with OS. While MTV and TLG were correlated with OS with p value of 0.045 and 0.031 respectively. Conclusion: The initial PET/CT MTV and TLG metabolic parameters are prognostic parameter for response and survival ismore efficient than the other metabolic parameters in patients with esophageal cancer.